Our bodies are made up of an endocannabinoid system (ECS) that uses naturally-occurring cannabinoids to maintain healthy cells and support our regulatory system. This central system helps to keep our bodies balanced day to day, including: appetite, pain sensation, mood, memory, immune system functions, and inflammation control. When there is a deficiency in these cannabinoids, it can lead to any number of conditions and medical ailments. CBD works to replenish these natural cannabinoids, and therefore return our cells to a healthy, balanced state.
CBD also interacts with various receptors sites called cannabinoid receptors found on cells in the brain and on your abdominal organs throughout the body:
5-HT1A Serotonin receptors: CBD has been shown to activate 5-HT1A serotonin receptors in the body, which can help alleviate anxiety, reduce nausea and vomiting, regulate appetite and improve sleep. They’re found in the central and peripheral nervous systems and stimulate many different chemical messages, which can either produce an excitatory or inhibitory response.
TRPV1 Vanilloid Receptors: CBD binds to TRPV1 receptors in the endocannabinoid system, which helps to reduce pain and inflammation, and regulate body temperature.
GPR55 Protein Receptors: cannabidiol acts as an antagonist to GPR55 protein receptors. By blocking it, CBD can help to hinder bone reabsorption and modulate blood pressure and bone density.
PPARs Nuclear Receptors: CBD plays a role in activating PPARs, located on the surface of the cell’s nucleus. By activating the PPAR-gamma receptor, CBD has an anti-proliferative effect on cancer cells. PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions.